翻訳と辞書 Words near each other ・ Indole-3-acetaldehyde oxidase ・ Indole-3-acetaldehyde reductase (NADH) ・ Indole-3-acetaldehyde reductase (NADPH) ・ Indole-3-acetate beta-glucosyltransferase ・ Indole-3-acetic acid ・ Indole-3-butyric acid ・ Indole-3-carbinol ・ Indole-3-carboxylate decarboxylase ・ Indole-3-glycerol-phosphate lyase ・ Indole-3-glycerol-phosphate synthase ・ Indole-3-pyruvate monooxygenase ・ Indole-5,6-quinone ・ Indoleacetaldoxime dehydratase ・ Indoleacetate—lysine synthetase ・ Indoleacetylglucose—inositol O-acyltransferase ・ Indoleamine 2,3-dioxygenase ・ Indolelactate dehydrogenase ・ Indolence ・ Indolent ・ Indolent Records ・ Indoleptipsius ・ Indolepyruvate C-methyltransferase ・ Indolepyruvate decarboxylase ・ Indolepyruvate ferredoxin oxidoreductase ・ Indolequinone ・ Indolestes ・ Indolestes boninensis ・ Indolestes divisus ・ Indolestes gracilis ・ Indolestes tenuissimus Dictionary Lists mini英和辞書 mini和英辞書 Webster 1913 Latin-English FOLDOC Wikipedia English ウィキペディア

翻訳と辞書　辞書検索 [ 開発暫定版 ] スポンサード リンク Indoleamine 2,3-dioxygenase ： ウィキペディア英語版 Indoleamine 2,3-dioxygenase Indoleamine-pyrrole 2,3-dioxygenase (IDO or INDO EC 1.13.11.52) is an enzyme that in humans is encoded by the ''IDO1'' gene. This enzyme catalyzes the degradation of the essential amino acid L-tryptophan to N-formylkynurenine.〔(【引用サイトリンク】 url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3620 )〕 == Function == Indoleamine 2,3-dioxygenase is the first and rate-limiting enzyme of tryptophan catabolism through kynurenine pathway, thus causing depletion of tryptophan which can cause halted growth of microbes as well as T cells. IDO is an immune checkpoint molecule in the sense that it is an immunomodulatory enzyme produced by some alternatively activated macrophages and other immunoregulatory cells (also used as an immune subversion strategy by many tumors). Interferon-gamma has an antiproliferative effect on many tumor cells and inhibits intracellular pathogens such as ''Toxoplasma'' and ''Chlamydia'', at least partly because of the induction of indoleamine 2,3-dioxygenase. 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「Indoleamine 2,3-dioxygenase」の詳細全文を読む スポンサード リンク 翻訳と辞書 : 翻訳のためのインターネットリソース Copyright(C) kotoba.ne.jp 1997-2016. All Rights Reserved.